Lenampicillin hydrochloride

Research use only, not for human use.

An efficient prodrug of ampicillin with enhanced absorption and decreased side effects.

An efficient prodrug of ampicillin with enhanced absorption and decreased side effects.

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Lenampicillin hydrochloride (KBT-1585)?(oral adminstration; 0-1000 mg/kg) does not lead to death in dogs, and maximum dose of in this acute toxicity study is recorded because of causing emesis.Lenampicillin hydrochloride (LAPC) areidentified for it main metabolites in rat and dogs. Themain metabolite in peripheral plasma is 2,3-butanediol in rats and dog, On the other hand, high levels of acetoin is found in portal plasma for early period after dosing of LAPC. These results shows that the biotransformation of promoiety in LAPC to acetoin carried out mainly in intestinal tissues, but acetoin is converted to 2,3-butanediol in liver.

KBT-1585 hydrochloride

GPCR/G Protein

Antibacterial

Antibacterial

Cancer

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80734-02-7

497.9492

C21H24ClN3O7S

>98% (HPLC)

10 mM in DMSO

O=C([C@@H](C(C)(C)S[C@]1([H])[C@@H]2NC([C@H](N)C3=CC=CC=C3)=O)N1C2=O)OCC4=C(C)OC(O4)=O.[H]Cl

4-Thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid, 6-[[(2R)-2-amino-2-phenylacetyl]amino]-3,3-dimethyl-7-oxo-, (5-methyl-2-oxo-1,3-dioxol-4-yl)methyl ester, hydrochloride (1:1), (2S,5R,6R)-

(-20℃)

With Ice Pack

≥ 2 years